Background: Prolonged exposure to sunlight is known to induce
photoaging of the skin, leading to various skin changes and disorders, such as dryness,
wrinkles, irregular pigmentation, and even cancer. Ultraviolet A (UVA) and ultraviolet B
(UVB) radiation are particularly responsible for causing photoaging. Objective: This
study aims to identify and compare photoaging rat models exposed to UVA and UVB.
Methods: This research method compared macroscopic (scoring degree of wrinkling) and
microscopic (histology) signs and symptoms on skin samples of rat exposed to UVA and UVB
for 4 weeks at a radiation dose of 840mJ/cm2. Results: The results of this study
indicated that the degree of wrinkling was highest in rat skin exposed to UVB rays by
51% (p [Med Arch 2024; 78(2.000): 88-91]

Disease, Photoaging model, Short-term exposure, UVA, UVB. Adipocytokines